【摘要】 [目的]探讨ACS患者血清MMP-2、hs-CRP和APN水平的变化及其相互关系。[方法]采用ELISA法测定72例ACS患者(包括49例不稳定型心绞痛(UAP)患者和23例急性心肌梗死(AMI)患者),42例稳定型心绞痛(SAP)患者和40例健康对照者的血清MMP-2,hs-CRP和APN水平,进行组间比较。同时将ACS各亚组与SAP组的血清MMP-2,hs-CRP和APN水平进行Pearson相关性分析。[结果](1)ACS组血清MMP-2水平和hs-CRP水平显著高于SAP组和对照组,而血清APN水平则显著低于SAP组和对照组。(2)ACS亚组和SAP组的比较中,AMI组血清MMP-2水平和hs-CRP水平显著高于UAP组和SAP组,而血清APN水平则显著低于UAP组和SAP组。(3)直线相关分析显示:UAP组的血清MMP-2与APN呈负相关(r=-0.289,P﹤0.05),hs-CRP与APN呈负相关(r=-0.347,P﹤0.05);AMI组的血清MMP-2与hs-CRP呈正相关(r=0.429,P﹤0.05),与APN呈负相关(r=-0.436,P﹤0.05),hs-CRP与APN呈负相关(r=-0.605,P﹤0.01)。[结论]血清MMP-2和hsCRP水平升高和APN下降均为ACS的危险因素,联合检测以上指标对冠心病患者危险分层及斑块稳定性监测具有重要的临床意义。更多还原

【Abstract】 [Objective] To investigate the change of serum MMP-2,hs-CRP and APN levels among patients with ACS and their relationship.[Methods] ELISA was used for detecting of 72 patients with ACS(including 49 cases of unstable angina pectoris(UAP) patients and 23 patients with acute myocardial infarction(AMI) patients),42 patients with stable angina pectoris(SAP) patients and 40 healthy.The serum MMP-2,hs-CRP and APN levels of patients with ACS and SAP group were compared.ACS while the sub-group and SAP group,levels of MMP-2,hs-CRP levels and APN were analyzed by pearson correlation analysis.[Results](1) serum levels of MMP-2 and hs-CRP levels in patients with ACS were significantly higher than the SAP group and control group,while the serum APN levels were significantly lower than the SAP group and Control group.(2) When comparing ACS sub-group with SAP group,AMI serum levels of MMP-2 and hs-CRP levels were significantly higher than the UAP group and SAP group,the serum APN levels were significantly lower than the UAP group and SAP group.(3) The linear correlation analysis showed that:APN serum MMP-2 in UAP group was negatively correlated(r =-0.289,P﹤0.05),the hs-CRP and APN showed negative correlation(r =-0.347,P﹤0.05);Serum MMP-2 and hs-CRP in AMI group was positively correlated(r = 0.429,P﹤0.05),and APN was negatively correlated(r =-0.436,P﹤0.05),hsCRP and APN presented negative correlation(r =-0.605,P﹤0.01).[Conclusion] Serum levels of MMP-2 and hsCRP were elevated,and the APN decreased in patients with ACS,combined detection of these indicators of coronary heart disease has important clinical significance in risk stratification and monitoring of plaque stability.更多还原