【摘要】 [目的]运用Meta分析方法综合分析评价月经生育因素与中国女性乳腺癌的关系。[方法]收集国内有关乳腺癌月经生育因素的病例对照研究文献22篇,采用可信区间方差分析法计算各相关因素的ORc及95%CI。[结果]各研究因素的ORc及95%CI分别为:初潮年龄ORc=0.540(0.450～0.648)、结婚年龄1.376(0.815～2.322)、初产年龄1.558(1.253～1.937)、生育与否0.718(0.320～1.616)、生育胎数0.97(0.705～1.335)、哺乳0.391(0.253～0.605)、哺乳时间0.94(0.884～0.999)、人工流产1.844(1.442～2.358)、绝经与否1.869(1.014～3.444)、绝经年龄1.034(0.706～1.515)、行经期1.223(1.034～1.446)、月经紊乱3.217(2.278～4.542)、月经周期0.446(0.372～0.535)、口服避孕药1.400(0.977～2.006)。[讨论]初潮年龄、哺乳和哺乳时间是乳腺癌的保护因素,初产年龄、人工流产、绝经及行经期是乳腺癌的危险因素,结婚年龄、生育、生育胎数、绝经年龄、月经紊乱、月经周期和口服避孕药与乳腺癌关系尚不明确,有待进一步研究。更多还原

【Abstract】 [Objective] To study the relationship between breast cancer and menstrual and reproductive factors in China with Meta analysis.[Methods] The results from 22 literatures about case-control studies on menstrual and reproductive factors of breast cancer were analyzed quantitatively and synthetically by meta-analysis,ORc and 95%CI were computed.[Results] Respectively the pooled odds ratio value of each factor was:age at menarche(y) OR=0.540(0.450-0.648),marriage age 1.376(0.815-2.322),primiparous age 1.558(1.253-1.937),reproduction 0.718(0.320-1.616),number of birth 0.97(0.705-1.335),breast-feeding 0.391(0.253-0.605),time of breast-feeding 0.94(0.884-0.999),abortion 1.844(1.4422.358),menostasia 1.869(1.014-3.444),age at menostasia 1.034(0.706-1.515),reproduction period 1.223(1.0341.446),menstrual disorder 3.217(2.278-4.542),menstrual cycle 0.446(0.372-0.535),oral-contraceptive use 1.400(0.977-2.006).[Conclusion] The protective factors influencing the incidence of breast cancer among Chinese females are age at menarche(y),breast-feeding and time of breast-feeding.The risk factors are primiparous age,abortion,menostasia and reproduction period.But the relationships are still unclear between marriage age,menstrual disorder,menstrual cycle,reproduction,number of birth,age at menostasia,oral-contraceptive use and breast cancer and it remains to be proved.更多还原