【摘要】 目的合成尼莫唑。方法以吗啉与氯乙醇反应,经羟基氯代,再在相转移催化剂存在下与4(5)-硝基咪唑缩合制得目标产物。结果产物经熔点测定、红外及核磁共振氢谱得到确认。结论该工艺路线方法简便,原料易得,适合工业化生产。更多还原

【Abstract】 OBJECTIVE To synthesis nimorazole.METHODS Nimorazole was prepared by reaction of morpholine with 2-chloroethanol,via chlorination,and condensed with 4(5)-nitro-imidazole in the presence of phase-transfer catalyst.RESULTS The structure was identified by mp.,IR and 1H-NMR.CONCLUSION The process can be easily controlled and suitable for a scale production.更多还原