【摘要】 目的探讨以痛为腧中药外涂治疗癌性疼痛的疗效和作用机制。方法将60例癌症患者随机分为2组,治疗组30例采用以痛为腧中药外涂治疗,对照组30例根据WHO三阶梯给药原则口服给药。治疗7 d,观察2组患者的镇痛有效率、平均止痛起效时间、持续时间、生活质量以及血液流变学指标。结果治疗组和对照组的总有效率分别为93%和90%,起效时间分别为(24.22±5.61)m in和(27.36±7.52)min,镇痛持续时间分别为(5.68±1.04)min和(5.89±1.76)min,2组比较均无显著性差异(P均>0.05);治疗组在改善生活质量、改善血液流变学指标及不良反应发生等方面均明显优于对照组(P均<0.05)。结论以痛为腧中药外涂治疗癌性疼痛是有效且安全的,其镇痛作用可能与改善血液流变学指标有关。更多还原

【Abstract】 Objective It is to approach the therapeutic effect and mechanism of external application of Chinese medicine on pain points in patients with cancer pain.Methods 60 patients with cancer pain were randomly divided into treatment group and control group,and with 30 cases in each group.The patients in treatment group were treated externally at pain points by external application of Chinese medicine,and the cases in control group were treated according to the WHO Three Step Administration Principle.After 7 days of treatment,analgesic effective rate,the average analgesic onset time,duration,life quality and hemorheological indexes were observed in two groups.Results The total effective rate in treatment group and control group were 93% and 90% respectively,the analgesic onset time were(24.22±5.61)min and(27.36±7.52)min respectively,analgesic durations were(5.68±1.04)min and(5.89±1.76)min respectively.There was no difference between medication group and control group in total effective rate,analgesic onset time and duration(P all >0.05),but the improvement of life quality,hemorheological indexes changes and the occurrence of side effects in treatment groups showed greater significance than in control group(Pall<0.05).Conclusion The external application of Chinese medicine at pain points on cancer pain is safe and effective,its efficacy may be related to the improvement of hemorheological indexes.更多还原