【摘要】 目的明确生殖器人乳头瘤病毒(HPV)感染的流行情况和亚型分布。方法用访谈和问卷调查收集尖锐湿疣患者的流行病学资料,应用基因芯片分型技术确定患者感染的HPV亚型,结合流行病学资料分析HPV的流行状况。结果 286份尖锐湿疣组织标本中,HPV单一型阳性率为77.97%(223/286),多重型别阳性率为22.03%(63/286),低危型阳性率为84.96%(243/286),高危型阳性率为15.03%(43/286)。21～50岁性活跃患者感染HPV6型的构成比高于其他年龄段(χ2=5.718,P<0.017),女性患者感染HPV11型的构成比高于男性患者(χ2=4.679,P<0.05)。结论武汉地区生殖器HPV感染以单一型、低危型为主,但高危型HPV感染有较高比例分布,提示加强生殖器疣防治,对预防相关的肿瘤具有重要意义。更多还原

【Abstract】 Objective To determine the epidemiological condition and distribution of subtypes of genital human papillomavirus (HPV) infection. Methods The epidemiologic data of the patients who suffered from genital warts were collected by interview and questionnaire,and subtypes of HPV were detected with the gene-chip techniques. Results A total of 286 tissue specimens of genital warts from the patients were detected,of whom 77.97%(223/286)were affected with single subtype of HPV,22.03%(63/286)were affected with multiple subtypes of HPV,84.96%(243/286)-with low-risk subtypes of HPV and 15.03%(43/286)-with high-risk subtypes of HPV; the rate of HPV-6 infection among sexual active groups aged between 21 and 50 years was higher than that in other groups (χ2=5.718,P=0.017),and the rate of HPV-11 among female patients was higher than among male patients (χ2=4.679,P<0.05). Conclusion Although the majority of HPV infections in Wuhan city are multiple subtype and low-risk subtype of HPV,high-risk subtype of HPV infection is also widely distributed,which indicates that it is of great significance for the prevention of the related tumor to control genital warts.更多还原