【摘要】 目的为了解苏北农村地区艾滋病家庭内二代传播的流行病学规律,分析艾滋病家庭内二代传播的发生率、夫妻之间传播率和母婴垂直传播的发生率。方法对铜山县1998-2008年间报告的166例艾滋病病毒(HIV)感染者/艾滋病(AIDS)病例进行回顾性调查,选择其中的110例进行分析。结果110例因受血感染HIV的已婚者中,男性28例,女性82例;夫妻间二代病例21例,男性13例,女性8例,艾滋病家庭内夫妻二代传播发生率为19.09%。男性传给女性的发生率为28.57%,女性传给男性的发生率为15.85%,两者的差异无统计学意义(χ2=2.4,P>0.05)。29名HIV抗体阳性的育龄妇女共生育活产婴幼儿33个,有6例确认HIV阳性,母婴传播发生率为18.18%。29名中11名妇女为感染HIV后生育,活产的15名婴儿中4名HIV阳性,母婴垂直传播发生率为26.67%;有18名是产后输血感染,活产18例婴幼儿均采取母乳喂养,有2例感染HIV,单纯母乳喂养造成的垂直传播发生率为11.11%。结论苏北农村地区艾滋病家庭内二代传播发生率较高,必须建立和完善艾滋病早期发现机制,遏制艾滋病向一般人群蔓延。更多还原

【Abstract】 Objective To investigate epidemiological features of the second-generation HIV/AIDS within family transmission in northern rural areas of Jiangsu province and to analyze prevalence of the second-generation within-family transmission as well as incidence of HIV infection between spouses and MTCT . Methods Retrospective study was conducted among 166 cases of HIV infectors /AIDS patients reported from 1998 to 2008 in Tongshan country of Jiangsu province. Results Among the 166 cases of HIV infectors /AIDS patients, 110 were married and got infected via blood transfusion, with 28 males and 82 females; 21 cases were couples of the second generation HIV transmission (13 males and 8 females) with the incidence rate of 19.09% ,of which 28.57% were cases of transmission from husbands to wives and 15.85%-vise verse ,but the deference had no statistical significance ( χ2 =2.4,P>0.05). Of the surveyed subjects , 29 HIV positive women of childbearing age delivered a total of 33 live babies, of whom 6 were confirmed as HIV positive with a MCTC rate of 18.18%. Of these 29 women 11 delivered their babies after they got infected with HIV, and of their 15 live babies 4 were HIV positive , with a MTCT rate of 26.67%, while 18 got infected via postnatal blood transfusion , and their 18 live babies all had breast feeding, of whom 2 were HIV positive ,with a MTCT rate of 11.11%. Conclusion The incidence of the second generation AIDS within-family transmission is relatively high in the rural areas of northern Jiangsu, and a system of early HIV case detection should be established and improved so as to contain the spread of HIV to the general population.更多还原