【摘要】 总结了最近发现的新型芳酰胺及芳酰肼大环一步合成反应,着重探讨了由分子内三中心氢键所引导的高效一步成环反应机理.这类反应是由未成环寡聚物前体的折叠构象所构筑,不仅高效,而且反应机理新颖,提供了传统成环反应难以得到的几类刚性大环的合成方法.这些大环化合物表现出对客体识别的高度专一性,并能形成具有高通量性的跨膜孔道.更多还原

【Abstract】 In this review, we summarize a newly discovered one-pot process for the synthesis of aromatic oligoamide and oligohydrazide macrocycles.A mechanism for these highly efficient one-pot macrocyclization reactions is presented and discussed.The unprecedented high efficiencies of these one-pot macrocyclization reactions are rationalized based on the folding of uncyclized oligomeric precursors, which is enforced by intramolecular hydrogen bonds.These one-pot macrocyclization reactions, with their unusually high efficiencies and novel mechanism, afford several new classes of shape-persistent macrocycles that are otherwise difficult to obtain using traditional methods.It has been already demonstrated that these macrocycles possess unique properties in the specific recognition of guest species and the formation of highly conducting transmembrane pores.更多还原