【摘要】 背景:胃食管反流病(GERD)为临床常见病,部分患者药物治疗效果不佳。不良生活方式和饮食习惯可影响GERD的发病,目前关于药物联合行为干预治疗GERD的研究报道尚少。目的:评估行为干预辅助治疗GERD患者胃食管反流症状的临床疗效。方法:120例GERD患者随机分为2组,研究组予埃索美拉唑20mg bid联合行为干预治疗,对照组仅予埃索美拉唑,疗程均为8周。治疗期间记录烧心、反酸、胸痛症状并分级,根据症状总体改善情况评估临床疗效。结果:研究组59例、对照组58例患者完成治疗方案。治疗8周末,研究组显效率和总有效率分别为76.3%和91.5%,对照组分别为58.6%和77.6%,组间差异有统计学意义(P<0.05)。结论:埃索美拉唑联合行为干预对GERD患者的胃食管反流症状有明显疗效。更多还原

【Abstract】 Background:Gastroesophageal reflux disease (GERD) is commonly seen in clinical practice,but in a portion of these patients drug therapy is not very effective,and unhealthy lifestyle,eating habit may affect the development of GERD.Currently,there are few reports concerning drug therapy in combination with behavior intervention in patients with GERD.Aims:To assess the clinical efficacy of behavior intervention as an adjunctive therapy for gastroesophageal reflux symptoms in patients with GERD.Methods:One hundred and twenty GERD patients were randomly divided into two groups.The study group was treated with esomeprazole 20 mg bid plus behavior intervention for 8 weeks,while the control group received esomeprazole only during the same period.Symptoms as heartburn,acid regurgitation and chest pain during the treatment course were recorded and graded for the assessment of clinical efficacy. Results:Fifty-nine patients in study group and 58 in control group completed the therapeutic regimen.After 8-week treatment,the marked effective rate and overall effective rate of study group were 76.3% and 91.5%,respectively,both were significantly higher than those of the control group (58.6% and 77.6%,respectively,P<0.05).Conclusions: Esomeprazole combined with behavior intervention is markedly effective for the treatment of gastroesophageal reflux symptoms in patients with GERD.更多还原