【摘要】 目的探讨双相障碍患者一级亲属的认知功能特点。方法选用10项神经心理测验对53例双相障碍患者未患病的一级亲属、97例正常对照个体进行认知功能的评定。结果亲属组的即刻逻辑记忆分为(9.11±2.95)分,明显差于对照组(12.06±3.21)分,差异具有统计学意义(P<0.01),亲属组的延迟逻辑记忆分为(6.89±3.41)分,明显差于对照组(10.06±3.30)分,差异具有统计学意义(P<0.01);亲属组的威斯康星卡片分类(WCST)测验分类数为(4.57±1.75)个,明显少于对照组(5.15±1.27)个,差异具有统计学意义(P<0.05)。结论双相障碍患者一级亲属可能具有言语记忆和执行功能障碍,其受损的认知功能可能是双相障碍的遗传"内表型"指标。更多还原

【Abstract】 Objective To investigate the cognitive functions in the first-degree relatives of patients with bipolar disorder.Methods 53 first-degree relatives of patients with bipolar disorder and 97 normal controls were tested by 10 neuropsychological tests.Results The scores of immediate logical memory tests in the in relatives(9.11±2.95)were worse than those in the normal controls(12.06±3.21)(P<0.01).Meanwhile,the scores of delayed logical memory tests in the relatives(6.89±3.41)were worse than those in the normal controls(10.06±3.30)(P<0.01).The numbers of WCST category in the relatives(4.57±1.75)were less than those in normal controls(5.15±1.27)(P<0.05).Conclusion The first-degree relatives of the patients with bipolar disorder had executive and verbal memory dysfunction,which may represent the genetic endophenotypes for bipolar disorder.更多还原