【摘要】 目的探讨喹硫平与帕罗西汀治疗抑郁发作的疗效和安全性。方法将150例抑郁发作患者分为喹硫平组和帕罗西汀组各75例,疗程8周,使用Montgomery-Asberg抑郁量表(MADRS)、汉密尔顿抑郁量表(HAMD)评定疗效,以治疗中出现的症状量表(TESS)评定不良反应。结果治疗8周两组MADRS、HAMD量表评分相当(P均>0.05),喹硫平组有效率为49例(65.3%),帕罗西汀组有效率为48例(65.8%);喹硫平组无转躁患者,而帕罗西汀组转躁4例;喹硫平组头晕、口干、便秘、体重增加的发生率明显多于帕罗西汀组。结论喹硫平与帕罗西汀治疗抑郁发作的疗效相当,无转躁现象,但前者头晕、口干、便秘、体重增加等不良反应较多见。更多还原

【Abstract】 Objective To detect the efficacy and safety of single quetiapine and paroxetine in the treatment of depression.Methods 150 patients with depression were assigned into quetiapine group and paroxetine group.Course of treatment was 8 weeks.Montgomery-Asberg depressive scale(MADRS),Hamilton depressive scale(HAMD)were applied to evaluate efficacy,and treatment emergent symptoms scale(TESS)was applied to evaluate side-effect of drugs.Results The two groups showed same in efficacy.No significant difference was found between the two groups on reducing score of MADRS,HAMD at the end of 8 weeks(P>0.05).There were 49(65.3%)patients in the quetiapine group and 48(65.8%) patients in the paroxetine group responded to drugs at the end of 8-week treatment.None of the patient receiving quetiapine switched into mania,but 4 patients in paroxetine group did.Patients in quetiapine group were more likely to have dizziness,dry mouth,constipation and other side effects than those in paroxetine group.Conclusion Single quetiapine and paroxetine were almost the same in efficacy.None of the patient receiving quetiapine switched into mania,but has frequently more dizziness,dry mouth,constipation and other side effects.更多还原