【摘要】 设计并合成了一种新型氟标记氨基酸类似物1-[18F]氟代乙基-L-色氨酸(1-[18F]FETrp)。以色氨酸为原料,采用有机合成法经过七步反应,合成了标准品1-[19F]FETrp;使用氟多功能模块,采用亲核取代法,将放射化学标记自动化。经过对1-[19F]FETrp自动化合成条件的摸索,最后采用二锅法合成了1-[18F]FE-Trp。1-[18F]FETrp的放化产率为1.5%,合成时间50 min;由于放化产率过低,今后需改变条件或者寻找新的合成路线以提高产率,以期为临床区分炎症和肿瘤提供新的PET显像剂。更多还原

【Abstract】 A novel [¹⁸F]fluoro amnio acid analogue 1-[¹⁸F]fluoroethyl-L-tryptophan(1-[¹⁸F]FETrp) was designed and synthesized.The cold standard 1-[¹⁹F]FETrp was synthesized by seven-step reactions,starting from tryptophan.Then fluoro-multifunctional chemistry process control unit（CPCU） was used to synthesize 1-[¹⁹F]FETrp by nucleophilic fluorination.1-[¹⁸F]FETrp was synthesized in a two-step semi-automated procedure.The no decay corrected radiochemica1 yield of 1-[¹⁸F]FETrp was 1.5% within 50 min total reaction time.Further experimental work is needed to improve the radiochemical yield,with the hope of attaining a satisfacting new PET imaging agent for differentiating the tumors and inflammation.更多还原