【摘要】 目的探讨血管紧张素Ⅱ受体拮抗剂对肾脏的保护作用机制。方法选取糖尿病肾病患者52例,随机分为治疗组和空白对照组,检测其24小时尿白蛋白(24h-UA lb)、尿转化生长因子β1(TGF-β1)、血浆内皮素(ET)在缬沙坦干预治疗前后水平的变化。结果试验终点缬沙坦干预组24小时尿白蛋白(24h-UA lb)总量,尿转化生长因子(TGF-β1),血浆内皮素(ET)明显降低(P<0.05;P<0.01),差异有显著性。结论血管紧张素Ⅱ受体拮抗剂(ARB)可能通过拮抗血管紧张素Ⅱ-1型受体(ATl-R)抑制RAS系统,起到降低尿蛋白,保护肾功能作用。更多还原

【Abstract】 Objective:To investigate the mechanism of angiotensinⅡreceptor antagonist on the renal protective effect.Methods: According to the standards of diabetic diagnosis and classification put forward by WHO in 1999,a total of 52 unrelated T2DM with DN(diabetic nephropathy) were randomly recruited in this study,And randomly divided into treatment group and control group.The levels of 24-hour urinary albumin(24h-UAlb),Urinary transforming growth factor β1(TGF-β1) and plasma Endothelin(ET) from all subjects were measured before and after the treatment with valsartan.Results:The levels of 24h-UAlb,uTGF-β1and ET were significantly decreased after the treatment with valsartan(P<0.05,P<0.01).Conclusion: Angiotensin Ⅱ receptor antagonist(ARB) may play an important role in reducing urinary protein and protection of renal function through inhibiting the RAS system.更多还原