【摘要】 对滇姜花粗提物、滇姜花素A(1)和姜花酮(2)进行了动物体内抗肿瘤活性测试,结果表明它们均能显著性抑制小鼠体内移植性肿瘤H22的生长,其中滇姜花素A对小鼠H22肿瘤生长抑制率达54.27%,作用最强。体外抗肿瘤实验发现,滇姜花素C(3)对体外培养的人类乳腺癌细胞株MDA-MB-231具有较强的细胞毒作用,并具有明显的剂量效应关系。更多还原

【Abstract】 The in vivo anticancer activity of yunnancoronarin A(1),hecychenone(2),and crude extract of hedychium yunnanense was tested here.Result revealed that yunnancoronarin A,hecychenone and the crude extractl showed significant inhibitory effect on H22 tumor in ICR mice.Yunnancoronarin A had the strongest inhibitory effect,with the inhibitory ratio of 54.27%.Yunnancoronarin C(3) also showed strong anticancer effect on human breast cancer cell line MDA-MB-231 in vitro.更多还原