【摘要】 目的:探讨甲状腺素受体β1(TRβ1)在乳腺癌组织中的表达及临床意义。方法:运用半定量逆转录聚合酶链反应(RT-PCR)技术检测40例乳腺癌及10例正常乳腺组织中TRβ1基因表达情况。结果:TRβ1基因在10例正常乳腺组织中全部表达,而TRβ1基因在40例乳腺癌组织中mRNA表达下降34例(85%)。乳腺癌组织中TRβ1基因表达明显低于正常乳腺组织(P<0.05)。不同年龄的患者TRβ1基因mRNA的表达差异无统计学意义(P>0.05),在不同临床分期、淋巴有无结转移、ER的阳性与阴性表达及肿瘤大小不同的患者中,TRβ1基因mRNA的表达差异有统计学意义(P<0.05)。结论:TRβ1在乳腺癌的浸润和转移方面起重要作用,可成为评估乳腺癌严重程度的新指标。更多还原

【Abstract】 Objective:To study the expression and clinical significance of thyroid hormone receptor β1(TRβ1) mRNA in breast cancer.Methods:The expression of TRβ1 mRNA was detected and analysed by using reverse-transcription PCR(RTPCR) in 40 cases of breast cancer and 10 cases of normal tissue.Results:The TRβ1 gene was expressed in all normal breast tissue.By contrast,reduced expression of TRβ1 was found in 34 of the 40 breast cancer tissue samples(85%).The expression level of TRβ1 was significantly lower in cancer group than that of normal group(P < 0.05).The expression of TRβ1 mRNA was significantly related with the depth of invasion,lymph-node metastasis and TNM stage(P < 0.05),but not related with age(P > 0.05).Conclusion:The expression of TRβ1 plays an important role in invasion and metastasis of the breast cancer.Detection of TRβ1 may be a new target for assessing the severity of breast cancer.更多还原