【摘要】 目的分析宫颈癌根治术并卵巢移位术术后患者的卵巢功能状况及其与血流阻力指数的关系。方法1997年8月至2004年9月间收治22例年龄26~40岁宫颈癌Ⅰa~Ⅱa期患者,均行宫颈癌根治术加单侧卵巢腹膜外移位术,按术后是否放疗分为放疗组12例,未放疗组10例,术后通过检测血清性激素水平,B超下测定卵巢血流阻力指数(RI)来评定移位卵巢的功能。结果放疗组术后24个月与术前相比,卵泡刺激素(FSH)升高,雌二醇(E2)明显降低,差异有统计学意义(均P<0.01);未放疗组术后各月与术前相比血清性激素水平差异无统计学意义(均P>0.05)。术后24个月两组激素水平比较,放疗组FSH升高,E2降低,与未放疗组相比差异有统计学意义(均P<0.05)。两组移位卵巢的血流阻力指数(RI)于术后24个月出现明显差异,放疗组的RI明显高于未放疗组(P<0.05),且放疗组RI与E2呈负相关(r=-0.901,P<0.01),与FSH呈正相关(r=0.895,P<0.01)。结论年轻宫颈癌患者行宫颈癌根治术并卵巢移位术后,监测卵巢功能与RI,RI与E2呈负相关,与FSH呈正相关,因此RI可作为监测卵巢功能的重要指标,并且术后辅助放疗是影响移位卵巢RI和内分泌功能的主要因素。更多还原

【Abstract】 Objective To investigate the relation of resistant index and function of transposited ovaries following radical hysterectomy in young women with early stage of cervical cancer.Methods A total of 22 young women(aged from 26 to 40 years old)with early stage of cervical cancer(FIGO Ⅰa or Ⅱa)were studied from Aug.1997 to Sep.2004 in the Affiliated Hospital of Inner Mongolia Medical Collage.Ovarian transposition was performed at the time of radical hysterectomy and pelvic lymphadenectomy in 12 cases who received postoperative radiotherapy;the rest 10 cases did not receive postoperative radiotherapy.Ovarian function was evaluated by serum FSH,LH,E2 and B-ultrasonography in all of the cases.Results There was a statistically significant difference between the radiotherapy group and the non-radiotherapy group in serum E2,FSH,LH levels and RI at the 24th month postoperatively.RI had a negative correlation with E2 and positive correlation with FSH.Conclusion Ovarian transplantation can preserve the endocrine function of ovary for young women with cervical cancer.RI has a negative correlation with E2 and positive correlation with FSH.RI is the important index of supervising ovarian function.Postoperative radiotherapy can influence RI and ovarian function.更多还原