【摘要】 [目的]观察氧化苦参碱对左冠状动脉前降支(LAD)结扎所致心力衰竭大鼠血流动力学的影响。[方法]采用结扎冠状动脉左前降支复制心力衰竭大鼠模型,药物干预8w后,采用导管法评估心功能。[结果]冠脉结扎8w后,模型组大鼠血流动力学各项指标与假手术组相比,差异显著(P<0.01)。各给药组大鼠血流动力学指标与模型组相比,有统计学意义(P<0.05～0.01)。[结论]氧化苦参碱能够改善心衰大鼠的血流动力学。更多还原

【Abstract】 [Objective]Observe the Hemodynamic of Oxymatrine on the left anterior descending coronary artery ligation induced heart failure rats.[Method]Use of the left anterior descending coronary artery ligation rat for 8 weeks to copy heart failure model.Evaluate the heart function using catheters methods.[Result]After about 8 weeks,there are Significant differences in the Hemodynamic between model group and Sham — operated group( P <0.01 ).There are differences in the Hemodynamic between treatment group and model group (P < 0.05 -0.01).[Conclusion]Oxymatrine coulde improve the hemodynamic of heart failure rats.更多还原