【摘要】 目的探讨肝郁血瘀型宫环出血病证动物模型的建立方法,并在此基础上进行发病机理的研究。方法本研究在肝郁证理论指导下,参照相关文献报道从慢性心理应激的角度出发,建立置Cu-IUD慢性束缚应激肝郁证大鼠模型,并分别观察了动物一般活动、体重改变及细胞因子的变化,并以药物反证模型。结果与正常对照组相比,模型组动物的一般活动均有改变,体重均有不同程度的减轻,快感缺失,有多种因子的水平发生了显著变化,而经疏肝化瘀药物治疗后各项情况得到明显改善。结论到目前为止,对肝郁证的评价还处于笼统、多指标、不确定状态,有待进一步多学科综合研究肝郁证的实质。更多还原

【Abstract】 Objective To investigate the methods of establishing liver depression and blood stasis Gonghuan hemorrhage syndrome animal model,and to research the pathogenesis on this basis.Methods Guided by the theory of stagnation of liver and the reference to other reports of chronic psychological stress,we established the chronic restraint stress with Cu-IUD rat models of liver depression syndrome(LDS),observed general activities,body weight changes and cytokine changes of the animals,and used drugs to disprove the models.Results As compared with normal control group,general activities of the animals in model group had changed,their body weights were reduced in varied degrees, and they lacked pleasure.There were several factors underwent significant changes,and the conditions had improved after treating by Shugan Huayu drugs.Conclusions So far,the evaluation of LDS is still in general,with many indicators and uncertainty.Multidisciplinary researches are needed to further evidence the real terms of LDS.更多还原