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绝经后妇女E2、β-CT_X、N-MID、PTH水平及相关性分析
Correlation Study on Serum Levels of E2,β-CTx,N-MID,and PTH in Postmenopausal Women
【摘要】 目的对绝经后妇女血清中E2、N-MID、PTH、β-CTX水平进行比较,探讨它们在PMOP发病机理中的作用。方法选取51例绝经前妇女为正常对照组,56例绝经后妇女为观察组,对两组E2、N-MID、PTH、β-CTX水平进行比较,并对N-MID、PTH、β-CTX与E2进行相关性分析。结果观察组E2比正常对照组有明显下降,差异有统计学意义(P<0.01),观察组N-MID、PTH、β-CTX水平比正常对照组有明显升高,差异有统计学意义(P<0.01),观察组N-MID、PTH、β-CTX与E2呈负相关。结论E2水平下降是PMOP发生的主要原因,E2、N-MID、PTH、β-CTX水平可作为PMOP的诊断与治疗依据。
【Abstract】 Objective To compare the serum levels of E2,N-MID,PTH,and β-CTX in postmenopausal women,and to explore their roles in the pathogenesis of postmenopausal osteoporosis (PMOP).Methods Fifty-one cases of premenopausal women were served as the normal control group,and 56 cases of postmenopausal women served as the observation group,serum levels of E2,N-MID,PTH,and β-CTX were compared between the two groups,and the correlation among N-MID,PTH,β-CTX,and E2 was analyzed.Results The serum level of E2 was significantly lower in the observation group than that in the normal control group,and the difference was statistically significant (P<0.01).The serum levels of N-MID,PTH,and β-CTX were significantly higher in the observation group than those in the normal control group,and the difference was statistically significant (P<0.01).E2 was negatively correlated with N-MID,PTH,and β-CTX in the observation group.Conclusions Decreased E2 level may result in PMOP.The serum levels of E2,N-MID,PTH,and β-CTX can be used as the clinical evidence for the diagnosis and treatment of PMOP.
【Key words】 Estradiol; β-Crosslaps; N-Osteocalcin; Parathyroid hormone; Postmenopausal osteoporosis;
- 【文献出处】 实用预防医学 ,Practical Preventive Medicine , 编辑部邮箱 ,2010年02期
- 【分类号】R580
- 【被引频次】6
- 【下载频次】115