【摘要】 目的探讨狼疮肾炎(LN)患者肾组织中肥大细胞(MC)、巨噬细胞、T细胞(CD4+,CD8+)的和转化生长因子(TGF)-β1与LN肾小管间质病变程度的关系。方法收集51例LN患者的肾活检标本,采用免疫组织化学技术检测MC、巨噬细胞、T细胞(CD4+,CD8+)的及TGF-β1在LN患者肾组织中的表达,并分析其与LN肾小管间质病变的关系。结果肾小管间质中浸润的CD4+细胞、CD8+细胞和CD68+细胞数量与对照相比差异均有统计学意义(P<0.05)。MC的表达与LN肾组织间质纤维化程度存在正相关关系(P<0.05);TGF-β1的表达及T细胞(CD4+,CD8+)、CD68+的巨噬细胞浸润与LN肾组织间质炎症存在正相关关系(P<0.05)。结论MC可能是LN肾间质纤维化的重要参与者;TGF-β1可能是MC、巨噬细胞和T细胞的重要趋化因子。更多还原

【Abstract】 Objective To detect the expression of mast cells(MC),macrophage(MΦ),T-cell,transforming growth factor(TGF)-β1 in kidneys of patients with lupus nephritis(LN),and to explore its correlation with the tubulointerstitial lesion(TIL)in LN.Methods The expression of MC,MΦ,T cells(CD4+,CD8+)and TGF-β1 in renal biopsy specimens from 51 cases with LN were detected by using immunohistochemical assay.Results The number of the infiltrated T cells(CD4+,CD8+)and CD68+ macrophage in cases with LN were significantly higher than that in the control group.There was a positive correlation between the expression of MC and renal interstitial fibrosis(P<0.05),and between the expression of CD68+ MΦ,T cells(CD4+,CD8+)and renal interstitial inflammation(P<0.05).Conclusion MC may be the major participant the in the renal interstitial fibrosis of LN,and TGF-β1 may be the important chemokines for the MC,MΦ and T cells.更多还原