【摘要】 目的研究雷公藤(Tripterygium wilfordiiHook.f.)根的化学成分。方法采用硅胶柱色谱、Sephadex LH-20、开放ODS柱色谱、HPLC等各种色谱技术对雷公藤根的化学成分进行分离纯化;根据理化常数测定和光谱分析对分离得到的化合物进行结构鉴定。结果从雷公藤根乙醇提取物中分离得到7个化合物,分别鉴定为2α,3α,23-三羟基乌苏烷-12-烯-28-酸(2α,3α,23-trihydroxyurs-12-en-28-oic acid,1)、2α,3α,23-三羟基乌苏烷-12,20(30)-二烯-28-酸(2α,3α,23-trihydroxyurs-12,20(30)-dien-28-oic acid,2)、2α,3α,24-三羟基乌苏烷-12-烯-28-酸(2α,3α,24-trihydroxyurs-12-en-28-oic acid,3)、2α,3α,19α-三羟基乌苏烷-12-烯-28-酸(euscaphic acid,4)、熊果酸(urasolic acid,5)、齐墩果酸(oleanolic acid,6)、2S,2′S-aurantiamide acetate(7)。结论化合物1、2、3、7为首次从雷公藤属植物中分离得到。更多还原

【Abstract】 Objective To study the chemical constituents from the roots of Tripterygium wilfordii Hook.f..Methods The constituents were isolated by chromatographic methods such as silica gel,ODS column chroma tography,Sephadex LH-20 and HPLC.Physico-chemical properties and spectroscopic analysis were employed for the structural identification.Results Seven compounds were obtained and their structures were identified as 2α,3α,23-trihydroxyurs-12-en-28-oic acid(1),2α,3α,23-trihydroxyurs-12,20(30)-dien-28-oic acid(2),2α,3α,24-trihydroxyurs-12-en-28-oic acid(3),euscaphic acid(4),ursolic acid(5),oleanolic acid(6)and aurantiamide acetate(7).Conclusions Compounds 123 and 7 are obtained from this genus for the first time.更多还原