【摘要】 目的探讨青年人缺血性脑卒中与抗心磷脂抗体(ACA)的关系及对预后的影响。方法测定青年人脑卒中组73例和健康体检者(对照组)30例患者血清ACA的阳性率,计算其异常率并进行比较。按脑卒中患者临床神经功能缺损程度评分(CNFDS)标准对患者进行评分。结果病例组ACA阳性率高于对照组(P<0.001);病例组中,ACA阳性者中多灶脑梗死率高于ACA阴性者(P=0.016);ACA阳性者中再发脑卒中高于ACA阴性者(P=0.040);病例组中ACA阳性者患者CNFDS评分较高,中位数为18(6～35),且预后不良。结论ACA可作为临床评价脑梗死严重程度和预后的生物学指标。更多还原

【Abstract】 Objective To explore the relationship between anticardiolipin antibodies(ACA) and ischemic stroke and its effect on the prognosis of brain infarction.Methods 73 young thrombosis patients and 30 healthy individuals as control were enrolled in the study.The serum level and abnormal rate of ACA were determined.All the patients were scored by clinic neurological function deficit scale(CNFDS).Results The rate of ACA in the thrombosis patients was higher than that in controls(P<0.001).The ACA positive rate in patients with multiple infarction was greater than that with single infarction(P=0.016).The ACA positive rate in patients with recurrent cerebral infarction was greater than that with first cerebral infarction(P=0.040).CNFD scores were higher in the patients of ACA positive(ranging 2 to 37,with a median of 12.5) than those of ACA negative(ranging 1 to 37,with a median of 4),with Mann-Whitney U test,P<0.01.And more severe prognosis was also found in the former than in the latter,with P<0.05.Conclusion Serum level of ACA is an important biological marker to evaluate the severity and prognosis of cerebral infarction.更多还原