【摘要】 目的分析血小板输注无效(PTR)的主要原因,为患者选择适用的血小板,用以提高输注疗效。方法对多次输血患者于输血前后监测血小板计数值,并计算1h和24h血小板增高指数(CCI值),对判断为血小板输注无效者,采用简易致敏血小板血清学枝术(SEPSA)进行血小板抗体筛查,并进行血小板交叉配型,对配合性输注效果进行分析。结果278例多次输血患者发生PTR共88例(31.7%);88例PTR患者中血小板抗体阳性67例(76.1%);67例抗体阳性患者,血小板交叉配型成功37例,血小板输注有效32例,有效率达86.5%。结论血小板抗体的产生是导致血小板输注无效的主要免疫性因素,血小板配合性输注能显著提高血小板输注效果。更多还原

【Abstract】 Objective To analyze the cause of platelet transfusion refractoriness(PTR)in order to improve platelet infusion effectiveness.Methods Platelet count was monitored in patients received blood transfusion repeatedly before and after blood transfusion.Corrected count increment(CCI)at 1 hour and 24 hours was used to determine the PTR.Platelet antibody was screened with simplified sensitized platelet serology assay(SEPSA)and followed by platelet cross-matching for patients with PTR.Results PTR was found in 88 of 278(31.7%)patients received repeatedly blood-transfusion.Of the 88 patients with PTR,67(76.1%)were anti-platelet antibody positive.Platelet cross-matching was successful in 37 of 67 anti-platelet antibody positive patients and platelet transfusion was efficient in 32 patients(86.5%).Conclusion Anti-platelet antibody production is a major immune factor that lead to PTR.Cross-matched platelet transfusion can significantly enhance the effect of platelet transfusion.更多还原