【摘要】 目的分析本地区人群出生缺陷发生情况和类型,为今后制定出生缺陷预防措施提供科学依据。方法对2002年6月～2004年8月期间纳入出生缺陷监测项目并随访分娩结局的围生儿(包括死胎、死产、病理性引流产、新生儿死亡)26 803例中的出生缺陷类型及地域分布进行分析。结果人群出生缺陷总发生率为134.31/万(360/26 803);360例出生缺陷中,71.67%(258/360)为产前诊断发现的,28.33%(102/360)为随访发现。出生缺陷前5位为先天性心脏病、唇腭裂、先天性脑积水、染色体异常、神经管缺损;按系统分类结果显示,面颈部畸形发生率最高,占3.21‰(86/26 803),其次为神经系统畸形,占2.72‰(73/26 803),循环系统和呼吸系统畸形占1.98‰(53/26 803),苏南、苏中、苏北围生儿肌肉骨骼系统出生缺陷发生率比较,差异有统计学意义(P<0.05)。结论减少出生缺陷的工作重点在预防,应加强优生知识的宣传,提高产前检查质量及产前诊断技术,以降低围生儿出生缺陷的发生率,提高出生人口素质。更多还原

【Abstract】 Objective To characterize the distribution patterns of birth defects in Jiangsu Province, 2002-2004.Methods Birth defects surveillance data in the period of June 2002-August 2004 were analyzed. Pregnancy terminations due to prenatal diagnosis,cases ascertained in stillbirths and livebirths were included.Results The overall prevalence rate of birth defects was 134.31/10 000 births.The first 6 common birth defects were congenital heart disease,total cleft lip and palate,congenital hydrocephalus, chromosomal abnormalities,and neural tube defects.Malformation in face and neck had the highest rate (3.21),followed by nervous system(2.72),and circulatory and respiratory systems(1.98).The prevalence rate of musculoskeletal birth defects in the Southern(1.06),Central(2.24),and North(2.71) of Jiangsu Province were significantly different.Of the 360 cases of birth defects,258 cases(71.67%) were diagnosed prenatally,and the other 102 cases post-natally(28.33%).Conclusion Musculoskeletal malformations distributed differently Jiangsu Province,and more than 70%of cases of birth defects were identified in the prenatal period.更多还原