【摘要】 目的 探讨脑胶质瘤病理良恶性分级与磁共振扩散张量成像(diffusion tensor imaging,DTI)的相关性。方法 搜集本院脑胶质瘤手术病人32例,该组患者术前均进行了完整的磁共振常规检查及DTI扫描,对于每一例患者分别于瘤中心、瘤边缘、正常区域脑白质3个位置测各项指标部分各向异性(FA)值、ADC值,每一病人每一部位测3次。搜集其病理分级、Ki67增殖指数等病理结果,并与DTI各项值进行相关分析。结果 瘤中心、瘤边缘、周围正常组织各部位FA值、ADC值均存在着显著差异,不同级别肿瘤的瘤中心FA值(后简称FA值)有显著性差别,且FA值与肿瘤分级呈正相关,FA值与Ki67增殖指数呈现明显正相关,且Ki67增殖指数与肿瘤分级呈正相关,而ADC值与Ki67、肿瘤分级之间均无相关性。结论 DTI检查,尤其是FA值对脑胶质瘤良恶性分级评估具有一定价值。更多还原

【Abstract】 Objective To discuss the correlation between MR diffusion tensor imaging(DTI) parameter and pathological grade in brain glioma.Methods 32 cases with brain glioma confirmed by pathology were collected.MR DTI examination before operation were carried out.DTI parameter including fractional anisotropy(FA) and apparent diffusion coefficient(ADC) were detected in the center,edge of the tumor and in the normal area of the brain respectively,the results were compared with pathological grade and Ki67.Results FA and ADC of the center,edge of the tumor and the normal area of the brain were different from each other.There was significant difference in FA between each grade of tumor,and there was positive correlation between FA and pathological grade,between FA and Ki67,between Ki67 and pathological grade.There were not correlation between ADC,Ki67 and the pathological grade.Conclusion MR DTI examination,especially FA value is of significant value in evaluating the grade of brain glioma.更多还原