【摘要】 目的:分析和评价复发鼻咽癌调强放疗(IMRT)的剂量学特点。方法:30例局部、区域复发的鼻咽癌患者使用IMRT的再程放疗,其中7例同时伴有颈淋巴结转移。根据1992年福州分期标准进行再分期,Ⅰ、Ⅱ、Ⅲ、Ⅳ期分别为7、7、4、12例。鼻咽大体肿瘤体积(GTV)处方剂量为58.80-78.76Gy,分次剂量2.0-2.92Gy。结果:治疗计划GTV的中位体积为37.46cm3(14.30-227.52cm3),覆盖鼻咽GTVD95的平均剂量为62.56Gy,GTVV95的平均体积为98.69%;靶区内GTV、CTV1和CTV2的平均剂量分别为65.82Gy、54.02Gy和50.20Gy;GTV的平均分割剂量为2.28Gy(2.0-2.92Gy)。结论:IMRT能较好覆盖肿瘤靶区而降低邻近敏感器官剂量。更多还原

【Abstract】 Objective:To report the dosimetric characteristic for locally recurrent nasopharyngeal carcinoma(NPC) treated with intensity modulated radiotherapy(IMRT).Methods:Thirty patients with local-regional recurrence in the nasopharynx were treated with full course IMRT.Seven patients had recurrence in the neck lymph node.According to the 1992 Chinese Fuzhou Staging System,7 patients had stageⅠ,7 stage Ⅱ,4 stage Ⅲ,and 12 stage Ⅳ.Prescription dose was 58.80-78.76 Gy in GTV,with the fractional dose of 2.28Gy (range,2.0-2.92 Gy).Results:The results of treatment plan showed that the median volume of GTV was 37.46cm3(range,14.30-227.52 cm3).The mean dose of covering gross tumor volume (GTV)(D95)in the nasopharynx was 62.56 Gy and the mean volume of (GTV)(V95) was 98.69%.The mean dose of GTV,clinical target volume CTV1 and CTV2 in the targets were 65.82Gy,54.02Gy and 50.20 Gy,respectively.The mean fractional dose of GTV was 2.28 Gy (range,2.0-2.92 Gy).Conclusion:Intensity modulated radiotherapy improves the target volume coverage and decreases the dose of nearby critical normal structure.更多还原