【摘要】 目的:探讨伴有复杂核型的急性早幼粒细胞白血病的临床和实验室特征。方法:应用常规细胞遗传学,间期荧光原位杂交技术(FTSH),多重荧光原位杂交技术,检测2例急性早幼粒细胞白血病。结果:常规细胞遗传学检测发现2例具有复杂核型,间期FISH证实2例均含有PML/RARA融合基因,多重FISH明确复杂核型性质。2例预后均较差。结论:联合常规细胞遗传学,间期FISH,多重FISH可以准确明确复杂核型的性质。具有复杂核型的急性早幼粒细胞白血病患者预后较差。更多还原

【Abstract】 Objective:To explore the clinical and laboratory characteristics of complex karyotypic abnormalities of acute promyelocytic leukemia.Methods:Multiplex fluorescence in situ hybridization was used in combination with conventional cytogenetics and interphase fluorescence in situ hybridization to study two cases of acute promyelocytic leukemia patients with complex karyotypic abnormalities.Results:Conventional cytogenetics detected complex chromosome abnormalities.All complex chromosome abnormalities were confirmed precisely by multiplex fluorescence in situ hybridization.Two patients had poor prognosis.Conclusion:Multiplex fluorescence in situ hybridization in combination with conventional cytogenetics may characterize the complex chrmosomal abnormalities more precisely.Acute promyelocytic leukemia patients with complex karyotype had a bad response to chemotherapy and poor prognosis.更多还原