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白藜芦醇对胃癌细胞HGC27细胞周期的影响
Effect of Resveratrol on the gastric carcinoma cells HGC27
【摘要】 目的:研究白藜芦醇对胃癌细胞株HGC27细胞细胞周期的影响。方法:不同浓度的白藜芦醇作用于HGC27细胞,用流式细胞术分析细胞周期。结果:白藜芦醇作用后,HGC27细胞的增殖速度减缓,DNA合成减少。白藜芦醇在较低浓度时即可诱导G0/G1阻滞。结论:白藜芦醇可诱导胃癌细胞发生G0/G1阻滞,S期减少。
【Abstract】 Objective:To study the effects of Resveratrol on the growth,development,cell cycle and apoptosis of gastric carcinoma cells HGC27.Methods:Cells were treated by different concentration of resveratrol,and analyze cell cycle by flow cytometry.Rusults:After the treatment with Resveratrol,HGC27 cells proliferated more slowly.The synthesis of DNA decreased.Resveratrol at low concentration can induce fast and reversible blockage at phase S.Conclusion:Resveratrol could induce gastric carcinoma cells apoptosis.Suitable concentration of resveratrol could prevent tumor in early stage.
- 【文献出处】 现代肿瘤医学 ,Journal of Modern Oncology , 编辑部邮箱 ,2010年01期
- 【分类号】R285;R735.2
- 【被引频次】7
- 【下载频次】236