【摘要】 目的:探讨脑出血后脑损害机制以及尼莫地平对脑出血后脑损害的保护作用。方法:将60例脑出血患者随机分为尼莫地平组与常规治疗组,患者均分别在治疗前后观察临床神经功能缺损评分、Barthel指数评分、血肿体积、水肿带体积。结果:治疗后临床神经功能缺损评分减少值尼莫地平组明显高于常规治疗组(P<0.01);尼莫地平组总有效率为73%,显著高于常规治疗组(40%,P<0.05)。治疗后BI评分增加值尼莫地平组明显高于常规治疗组(P<0.01);治疗后日常生活活动依赖程度尼莫地平组显著低于常规治疗组(P<0.05)。尼莫地平组和常规治疗组经治疗后血肿体积均明显缩小,尼莫地平组治疗后血肿体积减小值与常规治疗组治疗后血肿体积减少值比较无显著性差异(P>0.05)。尼莫地平组和常规治疗组治疗后水肿带均明显缩小,水肿带体积减少值尼莫地平组明显高于常规治疗组(P<0.01)。结论:临床神经功能缺损及临床残疾程度与脑出血后脑出血量、继发性脑水肿有着密切的关系。尼莫地平治疗脑出血有确切疗效,可减轻脑水肿,保护神经细胞,可减轻患者神经功能缺损程度,提高患者生活质量。更多还原

【Abstract】 Objective:To investigate the mechanism of succeed brain damage after intracerebral hemorrhage; to explore the protect effect of nimodipine on succeed brain damage after intracerebral hemorrhage. Methods:60 patients with intracerebral hemorrhage were randomly divided into nimodipine treat group and Normal treat group. The clinical neurological functional deficit scores,the Barthel index scores ,the hematoma volume and the edema area volume were observed before and after treatment. Results:The decrease amounts of the clinical neurological functional deficit scores in nimodipine treat group were much higher than that in normal treat group (P<0.01); the total efficiency in nimodipine treatment group (73%) were much higher than that of normal treat group (40%,P<0.05); the increase amount of BI in nimodipine treat group were much higher than that in normal treat group (P<0.01);the dependent level of every day life in nimodipine treatment group were much lower than normal treatment group(P<0.05); the hematoma volumes and the edema areas volumes after treatment reduced apparently in both groups,there was no significant difference of hematoma volumes between the decrease amounts of the hematoma volumes in nimodipine treat group and normal treat group (P>0.05) but the decrease amounts of the edema areas volumes in nimodipine treat group were much higher than that in normal treat group (P<0.01). Conclusion:The clinical neurological functional deficit scores and the clinical deformity degree have close relations with the hematoma volume and succeed cerebral edema after occurring cerebral hemorrhage. Nimodipine has a fine effect on treatment of cerebral hemorrhage,relieve cerebral edema,improve local cerebral ischemia ,protect the neural cells,relieve the clinical neurological functional deficit scores of patients and improve their living quality.更多还原