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细胞打印技术及应用

The Application of Cell Bioprinting

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【作者】 周丽宏陈自强黄国友翟晓陈咏梅徐峰卢天健

【Author】 ZHOU Li-hong1 CHEN Zi-qiang1 HUANG Guo-you1 ZHAI Xiao1 CHEN Yong-mei2XU Fong3 LU Tian-jian4(1 Biomedical Engineering and Biomechanics center,School of Aerospace,Xi’an Jiaotong University,Xi’an 710049,China)(2 Key laboratory for Non equilibrium condensed matter and Quantum engineering of Ministry of Education,School of Science,Xi’an 710049,China)(3 HST-Center for Biomedical Engineering,Department of Medicine,Brigham and Women’s Hospital,Harvard Medical School,Boston 510660,MA,USA)(4 Biomedical Engineering and Biomechanics Center,School of Aerospace,Xi’an Jiaotong University,Xi’an 710049,China)

【机构】 西安交通大学生物医学工程和生物力学研究中心航天航空学院西安交通大学理学院非平衡物质结构及量子调控教育部重点实验室HST-Center for Biomedical Engineering,Department of Medicine,Brigham and Women’s Hospital,Harvard Medical School

【摘要】 细胞打印技术是一种在体外构造具有生物活性的三维多细胞体系的先进技术。近年来,有关细胞打印技术的研究引起广泛的关注,其原因在于该领域具有明显的学科交叉与渗透融合的特点,它处于生命科学与快速成型技术、生物制造技术、生物科学和材料科学的交汇点。更加值得关注的是它为组织工程学突破二维研究的局限性,在三维尺度上精确控制与人体组织或器官相似的三维构造体方面的研究提供了一种新的思路。基于这一技术不仅在三维组织工程,还对细胞生物学、高通量药物筛选及细胞传感器等方面的前沿问题均有广阔的研究应用前景,介绍了近年来开发用于细胞打印的技术及其潜在的应用。

【Abstract】 Cell bioprinting can be defined as an advanced technology that fabricates 3D functional multi-cellular tissue in vitro.Due to its interdisciplinary characteristics,high resolution,cell bioprinting has been of considerable importance and popularity in recently.It is a powerful technology for tissue engineering and biological studies.Rather than a single approach,cell bioprinting includes a set of techniques(e.g.inkjet bioprinting,laser based techniques)that transfer biologically materials onto a substrate.Cell bioprinting also provides a new concept that how to construct more naturally 3D tissues or organs in vitro.The principle of these techniques was introduced,An overview of cell bioprinting in biological engineering applications,such as building 3D micro tissue,investigating cell biology,fabricating cell based microarray was also presented.

【基金】 国家自然科学基金杰出青年基金(No.10825210);陕西省自然科学基金青年项目(No.2010JQ1010);西安交通大学自由探索与自主创新项目(No.XJJ2010097)
  • 【文献出处】 中国生物工程杂志 ,China Biotechnology , 编辑部邮箱 ,2010年12期
  • 【分类号】Q819
  • 【被引频次】39
  • 【下载频次】1696
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