【摘要】 聚磷酸钙(CPP)是一种新型的可降解骨修复材料。针对CPP易脆和降解可控性方面的缺点,为了增加材料生物活性使结构更接近天然骨,选用与细胞外基质成分结构相近的壳聚糖(CS)及其衍生物羧甲基壳聚糖(CMC)为有机相;以醛基化海藻酸钠(ADA)作为天然交联剂,采用多次复合交联法分别制备了二元(CPP/CMC)和三元(CPP/CMC/CS)复合支架材料。通过在降解过程中,对支架材料的失重率、降解液的pH值、抗压强度及表面形貌变化的表征,研究了材料的降解规律。结果表明:多次复合CMC得到的支架材料界面接触良好,抗压强度显著提高,但二元复合支架有机相降解快;三元复合支架在降解可控性和力学性能上都表现出明显的改善。以上表明,三元复合支架材料的制备为骨组织工程用支架材料提供新的思路和可行的方法。更多还原

【Abstract】 Calcium polyphosphate(CPP) is a new type of degradable material for bone repair,yet it is fragile and is not so controllable in regard to degradation.For increasing biological activity and close proximity to natural bone structure,in this experiment,we chose chitosan(CS) and its derivative carboxymethyl chitosan(CMC) as the extracellular matrix structure for the organic phase.Aldehyde sodium alginate(ADA) was used as natural cross-linker.The binary(CPP/CMC) and ternary(CPP/CMC/CS) composite scaffolds were prepared by the "multiple composite-cross-linking method".The degradation laws of the two materials were investigated through the weight loss of scaffolds,the pH value of degradation solution,the compressive strength and the surface morphology characterization.The results showed that the composite scaffolds had good interface and the compressive strength increased greatly,but the organic phase of dual-phase composite scaffolds degraded quickly,while degradation controllability and mechanical properties of ternary composite scaffold were significantly improved.All the above findings show that the method of ternary complex scaffold preparation is useful for the design and preparation of bone tissue engineering materials.更多还原