【摘要】 组织工程半月板为临床严重的半月板损伤提供了一种新的治疗手段,而半月板支架材料是组织工程半月板的基本要素,也是近年来组织工程半月板研究的热点领域。近年来组织工程半月板支架材料无论是天然生物材料还是合成高聚物材料的研究都取得了可喜的进展。目前胶原半月板移植物(collagen meniscus implant,CMI)已经开始应用于临床。制成的水凝胶支架材料由于含水量高,结构与体内细胞外基质类似,生物相容性好,还为临床微创手术提供可能,因此在近年来成为研究热点。同时,综合各种支架材料优点的生物复合材料更是组织工程半月板支架材料研究的重点。本文通过广泛查阅近年有关组织工程半月板研究的文献并从支架材料的角度进行综述,为组织工程半月板研究提供参考。更多还原

【Abstract】 Tissue engineered meniscus provides a novel approach for the treatment of severe meniscus injury.The researches on scaffold for tissue engineered meniscus is an essential element.The researches on scaffolds for tissue engineered meniscus,including natural biomaterials and synthetic polymer,have made great advances in recent years.At present,collagen meniscus implants have been used in clinical practice.As hydrogel is characterized by having high water content and good biocompatibility,being similar to extracellular matrix in structure,and being able to provide access to microsurgery,it has become the hotspot field in recent years.Meanwhile,the combinatorial scaffold material advantages of biological composite tissue engineered scaffolds also illuminate the key point of research on meniscal scaffolds.This paper reviews the recent progress in betterment of the scaffolds so as to provide a theoretical and practical basis for further researches of tissue engineered meniscus.更多还原