【摘要】 全脑全脊髓照射是针对多种癌症的治疗流程中一个重要的组成部分。为了达到最佳的肿瘤控制,需要在靶区体积的确定、重要正常组织的保护、剂量均匀度、射野交接区域以及剂量测定方面都特别注意。本文提出了一种适用于大多数治疗情况的优化了的全脑全脊髓照射治疗技术,以一名因生殖细胞瘤需接受全脑全脊髓照射治疗的17岁男性患者为例,通过综合使用半野衔接技术、扩展半影的射野衔接技术和多叶光拦子野技术,制定临床可实行的治疗计划,大大改善了脊髓靶区内的剂量均匀度,将剂量最大点由处方剂量的124%降低到处方剂量的108%。对仿真人体模进行的实际测量值与计算值的比较表明,测量值和计算值是基本一致的。更多还原

【Abstract】 Craniospinal radiation is one of essential components in the treatment flow for a number of central nervous system malignancies.Meticulous attention to technique and dosimetry is required to produce optimum tumor control.In this paper,an optimized treatment regimen was proposed based on multiple techniques.The CT images for a 17-year-old male patient in need of craniospinal radiation were acquired for 3D conformal treatment planning.The split-beam technique,the extended penumbra fields matching technique,and the multiple leaf collimator segments and extended SSD technique were synthesized in the treatment regimen so as to work out an optimized treatment plan.The added few segments improved the dose homogeneity in spinal cord.The maximal point dose was decreased from 124% to 108% of the prescribed dose in it.Comparative study on the anthropomorphic phantom showed that the data collected by thermoluminescent detectors and the data obtained by calculation were basically coincident.These results suggest that the proposed technique be clinically acceptable.更多还原