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离体人氟斑牙脱矿与再矿化的研究

Study on Demineralization and Remineralization of Human Fluorosed Teeth in Vitro

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【作者】 罗丽娅黎红梁继超雷晓旭张慧彭生诚梁成文

【Author】 Luo Liya1 Li Hong2,1 Liang Jichao1 Lei Xiaoxue1 Zhang Hui1Peng Shengcheng1 Liang Chengwen11(State Key Laboratory of Oral Diseases,Sichuan University,Chengdu 610041,China)2(The Affiliated Hangzhou Stomatology Hospital,Second Clinical Medicine Institute,Zhejiang Chinese Medical University,Hangzhou 310053,China)

【机构】 四川大学口腔医学院口腔疾病研究国家重点实验室浙江中医药大学第二临床医学院杭州口腔医院

【摘要】 通过研究不同严重程度人氟斑牙在体外经人工龋脱矿实验及再矿化处理前后,釉质表面显微硬度值的变化,探讨氟斑牙的严重程度与脱矿再矿化的关系。结果发现:脱矿后氟斑牙的表面显微硬度损失百分比(%SMHD)为TFI4(18.92±1.31)<TFI3(20.50±1.32)<TFI2(25.08±1.69)<TFI1(27.77±1.79)<TFI0(30.70±1.35),(P<0.05),轻度氟斑牙TFI1(27.77±1.79)与对照组正常牙TFI0(30.70±1.35)没有显著统计学差异。再矿化处理后氟斑牙的表面显微硬度恢复的百分比(%SMHR)为TFI1(55.17±4.03)>TFI0(53.97±4.96)>TFI2(49.17±3.11)>TFI3(44.85±3.21)>TFI4(36.51±2.95)(P<0.05);中重度氟斑牙的抗龋性显著高于轻度氟斑牙及正常牙,轻度氟斑牙再矿化的效果明显好于中重度氟斑牙,同时也比正常牙稍好。值得临床注意。

【Abstract】 This study sought to determine the impact of dental fluorosis severity on demineralization and remineralization of human fluorosed teeth in vitro.Surface enamel microhardness was measured on the enamel blocks before and after demineralization and after remineralization.The results showed that after demineralization,the sequence of % Surface microhardness demineralization(%SMHD)was TFI4(18.92±1.31)<TFI3(20.50±1.32)<TFI2(25.08±1.69)<TFI1(27.77±1.79)<TFI0(30.70±1.35)(P<0.05),and there was no statistically significant differences between TFI1(27.77±1.79) and the normal group TFI0(30.70±1.35).After remineralization,the sequence of % Surface microhardness remineralization(%SMHR) was TFI1(55.17±1.23)>TFI0(53.97±3.05)>TFI2(49.17±1.81)>TFI3(44.85±1.89)>TFI4(36.51±2.95)(P<0.05).Moderately fluorosed enamel showed a significatnt resistance to caries,but mildly fluorosed enamel could get better remineralization.These facts and figures deserve clinicians’ attention.

【关键词】 氟斑牙人工龋再矿化显微硬度
【Key words】 Fluorosed teethEarly cariesRemineralizationMicrohardness
【基金】 四川省科技支撑项目资助(2009FZ0065);教育部留学回国人员科研启动基金资助项目(2008890);国家自然科学基金重点项目资助(50535050)
  • 【文献出处】 生物医学工程学杂志 ,Journal of Biomedical Engineering , 编辑部邮箱 ,2010年01期
  • 【分类号】R78
  • 【被引频次】1
  • 【下载频次】252
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