【摘要】 目的:探讨血清肿瘤坏死因子-α(TNF-α)、白介素(IL)-1、-6和-8在大鼠暴发性急性胰腺炎(FAP)中的作用。方法:建立大鼠FAP模型,检测各时点(0、6、12、24、48、72和120 h)胰腺组织病理评分(PM)和干湿重比率以及血清TNF-α、IL-1、-6和-8的变化。结果:实验组PM和干湿重比率在造模后6 h起各时点均与对照组比有统计学意义(P<0.01);血清IL-1水平6 h开始升高并达高峰,以后逐渐降至正常水平;TNF-α水平变化呈双峰型升高;IL-6和-8均在24 h升高并达高峰,其后逐渐降至正常水平。结论:大鼠FAP中TNF-α、IL-1(始动因子)、-6和-8水平皆升高。更多还原

【Abstract】 Objective: To explore the roles of tumor necrosis factor(TNF)-α,interleukin(IL)-1,-6 and-8 in FAP of rats.Methods: FAP models of rats were established.The changes of TNF-α,IL-1,-6 and-8 in serum were determined at all time points(0,6,12,24,48,72 and 120 hours).PM and dry and wet ratio were analyzed.Results: There was significant difference between two groups on PM and dry and wet ratio from all time points(P<0.01).Serum IL-1 increased and peaked at 6 hours,and decreased to normal level gradually.The level of serum TNF-α was bimodal pattern increase.IL-6 and8 both increased and peaked at 24 hours,then decreased to normal level gradually.Conclusion: In rat FAP models,the levels of TNF-α,IL-1(initiator),-6 and-8 increase.更多还原