【摘要】 目的:探讨甘草苷抗小鼠脑缺血再灌注炎性损伤作用及机制。方法:将ICR小鼠随机分为假手术组、模型组、阳性对照组(依达拉奉3mg/(kgbw·d)和甘草苷高、中、低剂量(40、20、10mg/(kgbw·d))组。采用线栓法建立局灶性脑缺血再灌注损伤模型,缺血2h再灌注22h后,观察脑组织病理学变化、测定髓过氧化物酶(MPO)活性,检测细胞间黏附因子-1(ICAM-1)表达。结果:与模型组相比,甘草苷可明显减轻脑组织病理学改变,降低MPO活性及ICAM-1表达。结论:甘草苷具有抗脑缺血再灌注炎性损伤活性。更多还原

【Abstract】 Objective: To investigate the protective effect and mechanism of liquiritin against cerebral ischemia/reperfusion inflammatory injury in mice. Methods: ICR mice were randomly divided into sham group, model group, positive control group (intraperitoneally administered edaravone, 3 mg/(kg bw·d)), and liquiritin groups (intragastrically administered, 40, 20 mg/(kg bw·d) and 10 mg/(kg bw·d)). Focal cerebral ischemia/reperfusion models were set up by using intraluminal filament method. After cerebral ischemia for 2 h and subsequent reperfusion for 22 h, histopathology changes were monitored, and the activity of MPO and the expression of intercellular adhesion molecule-1(ICAM-1) in brain tissue were measured. Results: Compared with the model group, liquiritin noticeably decreased the activity of MPO and the expression of ICAM-1. Conclusion: Liquiritin has protective effects against cerebral ischemic/reperfusion inflammatory injury.更多还原