【摘要】 目的:观察水牛初乳粉对Ⅰ型糖尿病大鼠血清抗氧化水平及脏器指数的影响。方法:采用腹腔注射65mg/kgbw链脲佐菌素诱导建立糖尿病大鼠模型,大鼠随机分为正常组、糖尿病模型组、药物组和水牛初乳组,正常组和糖尿病模型组灌胃灭菌水,药物组和水牛初乳组分别灌胃盐酸二甲双胍和水牛初乳粉溶液,定期检测血糖,第31天采血,用比浊法检测血清抗氧化指标,并称取各脏器质量,计算脏器指数。结果:水牛初乳能够降低糖尿病初期大鼠的血糖(P<0.01和P<0.05),显著提高大鼠血清SOD活力(P<0.01),显著降低血清NO含量(P<0.05),使胰脏和肺脏指数显著减小(P<0.01和P<0.05)。结论:水牛初乳粉能够控制Ⅰ型糖尿病初期大鼠的血糖值,增强机体的抗氧化能力,减轻氧化应激程度,并保护胰腺和肺脏。更多还原

【Abstract】 Effects of water buffaloes colostrums powder (WBCP) on serum anti-oxidative activity and organic indexes in insulin-dependent diabetes mellitus (IDDM) rats were studied. Insulin-dependent diabetes mellitus rats were induced by intraperitoneal injection of STZ with high-dose of 65 mg/kg bw. Rats were randomly assigned to normal group, diabetic model group, medicine group and WBCP group. With intragastric administration, sterilized water were provided to the normal and the diabetic model group, while metformin and WBCP groups were supplied for the medicine group and the WBCP group daily, respectively. Blood sugar level in fasting rats was determined regularly and blood samples were collected on day 31. Serum anti-oxidative activity was determined and internal organs were weighed and organic indexes were calculated. Compared with the diabetic model group, fasting blood sugar level drop at the beginning (P<0.01 and P<0.05) and serum SOD activity increased (P<0.01), however NO concentration decreased (P<0.05) in the WBCP group. Moreover, pancreas index and lung index decreased (P<0.01 and P<0.05). In conclusion, WBCP can maintain the fasting blood sugar level at the beginning and oxidative stress is attenuated in IDDM rats with pancreases and lungs being protected.更多还原