【摘要】 目的:探讨大黄丹皮汤灌肠对创伤后炎症反应综合征(SIRS)患者细胞因子和自由基的影响。方法:151例符合SIRS诊断的患者随机分为3组,常规治疗组49例、大黄组51例、大黄丹皮汤组51例。于治疗第1、3、7天进行急性生理慢性健康评分系统Ⅱ(APACHE-Ⅱ)评分,检测患者血清肿瘤坏死因子α(TNF-α)、白介素-1β(IL-1β)、白介素-4(IL-4)、白介素-6(IL-6)、白介素-10(IL-10)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、脂质过氧物丙二醛(MDA)和一氧化氮(NO)。结果:各组患者治疗后APACHE-Ⅱ评分均显著下降(P<0.05),其中大黄丹皮汤组下降最明显(P<0.05)。各组患者治疗后TNF-α、IL-6、IL-10水平均逐渐下降;IL-4水平在治疗第3天明显增高,在第7天出现下降;IL-1β在治疗期间无明显波动。SOD活性和MDA水平治疗后逐渐下降,而GSH-PX活性和NO水平则逐渐升高。对IL-6、MDA、GSH-PX、NO等指标的干预作用大黄丹皮汤组优于大黄组。结论:大黄丹皮汤灌肠治疗能够调控炎性反应系统/抗炎性反应,具有清除自由基和抗脂质过氧化的作用。更多还原

【Abstract】 Objective: To investigate the effects of retention enema of "Dahuang Danpi Decoction"on cytokines and free radicals in patients with post-traumatic systemic inflammatory response syndrome(SRIS)Methods: A total of 151 patients with SIRS were randomly divided into three groups as following:49 patients in routine therapy group,51 patients in "Dahuang"group and 51 patients in "Dahuang Danpi Decoction"group.On the lst,3rd and 7th day of treatment,the acute physiology and chronic health evaluation Ⅱ(APACHE-Ⅱ) scoring was performed;tumor necrosis factor a(TNF-a),interleukinⅠβ(IL-Ⅰβ),IL4,IL-6,IL-10,superoxide dismutase(SOD),glutathione peroxidase(GSH-PX),lipid peroxide malondialchehyche(MDA)and nitric oxide(NO) were determined respectiveiy.Results: APACHE-Ⅱ decreased significantly in both treatment groups(P<0.05),and the decrease in "Dahuang Danpi Decoction"group was more significant of the two(P<0.05).Contents of TNF-a,IL-6 and IL-10 decreased gradually during the therapy period;the content of IL-4 increased on the 3rd day,but then decreased on the 7th day;the level of IL-βdid not change in the treatment period;the activity of SOD and content of MDA decreased,however the activituy of GSH-PX and NO content elevated.The effects of "Dahuang" group.Conclusion: Retention enema with "Dahuang Danpi Decoction"could modulate the inflammatory and anti-inflammatory reaction,and has the effects of eliminating free radicals and anti-lipid peroxidation.更多还原