【摘要】 目的 探讨NaYF₄纳米颗粒宫颈注射后在家兔盆腔淋巴结聚集情况，并探讨聚集的最佳直径和最佳时间点。方法 10%NaYF₄纳米颗粒（Φ20、50、100 nm）溶液注射家兔宫颈，注射后（2、10、30、60、120 min）分别取盆腔淋巴结制成切片，观察荧光颗粒的聚集情况，并用浓硝酸消化组织后定量检测NaYF₄纳米颗粒浓度; 10%50 nm NaYF₄纳米颗粒溶液注射家兔宫颈10 min后取盆腔淋巴结、肝脏、肾脏和脾脏，并用浓硝酸消化组织后定量检测NaYF₄纳米颗粒浓度。结果 50 nm是NaYF₄纳米颗粒溶液注射家兔宫颈在盆腔淋巴结聚集的最佳直径，10 min是最佳时间点;家兔盆腔淋巴结中NaYF₄纳米颗粒的量大于肝、脾和肾等脏器的量。结论 NaYF₄纳米颗粒溶液经宫颈注射后能够在家兔的盆腔淋巴结中富集。更多还原

【Abstract】 Objective To investigate whether there is enrichment of NaYF₄ nano-particles in pelvic lymph node by cervical injection in rabbits, and also to decide the peak time and the best diameter of nano-particles. Methods 10% solution with different diameters of nano-particles（20、50、100 nm）is injected through female rabbit’s cervix. The pelvic lymph nodes were be taken at different time（2、10、30、60、120 min） after injection and the aggregation peak of nano-particles were measured;in10 min 50 nm group, the liver、spleen and kidneys are taken with pelvic lymph nodes together to detect the aggregation characteristics of nano-particles. Result The 50 nm is a preferable NaYF₄nano-particles diameter for NaYF₄ solution injection through cervix, and 10 min is the peak time.Compared with the liver, spleen and kidneys, more nano-particles were aggregated in pelvic lymph nodes. Conclusion NaYF₄ nanoparticle solution through cervical injection of the pelvic lymph nodes in rabbits can be enriched.更多还原