【摘要】 哺乳动物呼肠孤病毒吸附和侵入宿主细胞是感染启动的关键一步，包括病毒表面蛋白的不同区域同细胞表面不同的受体发生相互作用。病毒表面蛋白包括三种：s1、s3和m1，这三种蛋白在与受体的结合上具有不同的作用。细胞表面的受体包括唾液酸、JAM-1，未知的碳水化合物等，这些受体在病毒吸附和侵入细胞时能特异性的与病毒表面蛋白结合，被认为是病毒宿主范围和组织嗜性的一个决定因素，因此，受体与表面蛋白的相互作用的研究有助于揭示病毒的感染途径及细胞内的复制过程。本文简要介绍近年来在这方面的研究进展。更多还原

【Abstract】 It is a key step that Mammalian reovirus adhesion and entry into the host cells during the infection, including that the different domains on the outer capsid protein interact with the different receptors on the surface of host cells. There are three kinds of virus capsid protein σ1, σ3, and μ1,playing important roles of the binding of reovirus to receptors on the surface of host cells. The reovirus strains use Sialic Acid(SA), junctional adhesion Molecule-1, cell surface carbohydrate as the receptors,which could bind to the surface protein of the virus specifically and explain both cell-type specific tropism and broad hosts, thus, the research on the virus-receptor interactions are conducive to reveal the pathogenesis and replication. This review will summarize recent advances made in studies of reovirus outer capsid protein and Receptor.更多还原