【摘要】 目的:探讨甲氨蝶呤两种应用方法联合米非司酮治疗异位妊娠的临床疗效和不良反应,指导临床用药。方法:对128例确诊异位妊娠的患者,随机分为A、B两组。A组64例:甲氨蝶呤0.4mg/(kg·d),肌内注射5天,联合米非司酮25mg,每天2次口服,用3天;B组64例:甲氨蝶呤1mg/kg,单次肌内注射,联合米非司酮25mg,每天2次口服,用3天,观察两组的临床疗效和不良反应。结果:当血β-HCG定量<2000U/L时,使用A组方案治疗异位妊娠的治愈率为98.43%,B组为95.31%,差异无统计学意义(P>0.05);A组Ⅱ度、Ⅲ度胃肠道反应及血细胞计数下降发生率明显高于B组,差异有统计学意义(P<0.05)。结论:对于较低血β-HCG水平的异位妊娠患者使用甲氨蝶呤1mg/kg单次肌内注射联合米非司酮治疗,疗效好且更为安全。更多还原

【Abstract】 Objective:To investigate the clinical efficacy and adverse reaction of two dosages of methotrexate(MTX) combined with mifepristone for treatment of ectopic pregnancy and guide clinical medication.Methods:128 patients with confirmed diagnosis of ectopic pregnancy were randomly divided into A and B group.64 patients in A group were given methotrexate 0.4 mg/(kg·d)intramuscular injection for 5 days combined with mifepristone tablets 25 mg taken by oral twice per day for 3 days.64 patients in B group were given a single intramuscular injection of MTX 1 mg/kg and mifepristone tablets 25 mg taken by oral twice per day for 3 days.The clinical efficacy and adverse reaction were observed and analyzed in two groups.Results:When the serum quantitation of β-HCG was <2000 U/L,the cure rate of ectopic pregnancy in group A was 98.43%,in group B was 95.31%.There was no significant difference (P>0.05).The incidence of Ⅱ,Ⅲ degree of gastrointestinal reactions and decrease of blood cell count in group A was significantly higher than that in group B.There was significant difference(P<0.05).Conclusions:It is a safe and effective method for the patients with ectopic pregnancy in lower levels of serum β-HCG by using a single injection of methotrexate 1mg/kg combined with mifepristone tablets 25mg taken by oral twice per day for three days.更多还原