【摘要】 目的:了解热休克蛋白40(heat shocking protein,Hsp40)在卵巢上皮性癌中的表达并分析其与临床病理的相关性。方法:用免疫组织化学方法(immunohistochemistry,IHC)检测了45份卵巢上皮性癌、20份卵巢良性肿瘤、20份正常卵巢组织中Hsp40蛋白的表达情况,将其表达结果与临床病理资料进行统计学分析。结果:Hsp40蛋白在卵巢上皮性癌组织中表达的强度及阳性表达率明显高于卵巢良性肿瘤、正常卵巢组织,阳性表达率分别为62.2%、25.0%、20.0%,差异有高度统计学意义(P<0.01);卵巢上皮性癌组织中Hsp40蛋白表达与其临床分期、组织学分级、有无远处转移及有无残余灶无明显相关性。Kaplan-Meier生存曲线及Log-rank分析显示Hsp40蛋白表达阴性者的生存时间明显长于阳性表达者,差异有高度统计学意义(P<0.01)。Cox模型显示残余病灶的大小单独进入Cox模型,而Hsp40蛋白表达并不影响预后。结论:Hsp40蛋白可能在卵巢上皮性癌的发生、发展起重要作用。更多还原

【Abstract】 Objective:The expression of Hsp40 in epithelial ovarian cancer and its correlation with clinical pathology were investigated.Methods:The expression of Hsp40 was detected by immunohistochemistry in 45 cases of epithelial ovarian cancer and 20 cases of benign ovarian tumor and 20 cases of normal ovary. Statistical analysis was done to correlate the expression of Hsp40 with pathological characteristics.Results:The expression of Hsp40 in epithelial ovarian cancer was significantly higher than benign ovarian tumor and normal ovary, the positive rates were 62.2%,25.0% and 20.0% respectively (P<0.01). There was no significant correlation between the expression of Hsp40 and clinical stages, histological grades,with or without metastasis, with or without residual tumor. Kaplan-Meier survival curves and Log-rank analysis showed that the survival time in Hsp40 expression negative patients was significantly longer than those positive expression patients(P <0.01). Cox analysis showed residual tumor size was the only one covariant factor, the expression of Hsp40 was not significantly relevant to prognosis.Conclusions:Hsp40 may play an important role in the occurrence and development of epithelial ovarian cancer.更多还原