【摘要】 目的观察辽宁地区健康汉族人群中白细胞介素-6(IL-6)基因-572C/G多态性。方法选择辽宁地区366例健康汉族人,采用聚合酶链反应—限制性片段长度多态性技术检测其血清中IL-6基因的-572C/G多态性。结果辽宁地区健康汉族人IL-6基因-572C/G基因型中CC、CG、GG型频率分别为63.93%、34.15%、1.92%。C等位基因与G等位基因频率分别为81.01%、18.99%。结论辽宁地区健康汉族人IL-6基因在-572C/G存多态性,其中CC纯合子最多见,CG杂合子次之,GG纯合子最少见;C等位基因为常见基因,G等位基因为少见基因。更多还原

【Abstract】 Objective To observe the frequencies distribution of interleukin-6(IL-6) gene-572C/G polymorphism in health chinese Han population in Liaoning.Methods Polymerase chain reaction-restrion fragment length polymorphism(PCR-RLFP) was used to test a coding variant IL-6-572C/G gene in 366 cases of Liaoning Han population with normal glucose tolerant,and it was compared with the genotype and allele frequencies of IL-6 in different healthy population from English,French,koreaa,American,and other countries.Results In Liaoning healthy population,572CC、CG and GG genotype frequencies were 63.93%,34.15%,1.92%,respectively.-572 C and G allele frequencies were 81.01%,18.99%,respectively.These were similar to those in koreaa and Japanese,but significantly different from those in English,French,American,Italian and Denmark population.Conclusion There is interleukin-6(IL-6) gene-572C/G polymorphism in health chinese Han population in Liaoning.C allele is usual and G allele is rare.更多还原