【摘要】 目的探讨扩张型心肌病(DCM)患者外周血CD4+CD2+5T细胞变化及临床意义。方法采用流式细胞分析法检测30例DCM患者(DCM组)及20例健康者(对照组)的外周血CD4+CD2+5T细胞。结果外周血CD4+CD2+5T细胞占CD4+T细胞的比例DCM组为(8.53±1.64)%,对照组为(11.4±2.17)%,两组比较有统计学差异(P<0.01);且DCM患者心功能越差,CD4+CD2+5T细胞占CD4+T细胞的比例越低。结论DCM患者CD4+CD2+5T细胞比例减少,可能打破自身免疫耐受,发生针对心肌抗原的免疫反应,参与DCM发病。更多还原

【Abstract】 Objective To explore the significance of the change of CD+4CD+25T cells in peripheral blood in patients with dilated cardiomyopathy(DCM).Methods The frequencies of CD+4CD+25T cells were detected in 30 patients with DCM(DCM group) and 20 healthy donors(control group) by flow cytometry.Results The ratio of CD+4CD+25T cells/CD+4T cells was found to be significantly lower in DCM group[(8.53±1.64)%] than those of control group [(11.4±2.17)%](P<0.01).The ratio of CD+4CD+25T cells/CD+4T cells had negative correlation with New York heart association functional classification.Conlusion The decreased ratio of CD+4CD+25T cells/CD+4T cells may lead to the down-regulation of autoimmune tolerance and brings about immunoreaction aiming directly at myocardium,which participates in the genesis of DCM.更多还原