【摘要】 目的观察栗酮对高脂饮食所致脂肪肝大鼠血脂及胆固醇的影响。方法大鼠用4%胆固醇,30～40℃猪油灌胃诱发高脂血症。设栗酮300,150,75 mg/kg 3个剂量组,灌胃栗酮60 d后采血检测血清总胆固醇、甘油三酯以及高、低密度脂蛋白。处死动物,剖取肝脏肉眼观察及光镜检查肝脂变程度。结果大鼠栗酮300,150 mg/kg组血清总胆固醇、甘油三酯、低密度脂蛋白水平明显降低,与高脂模型组相比有显著差异,对高密度脂蛋白影响不大。病理检查结果表明,栗酮组300,150 mg/kg均能明显减轻肝细胞脂变。结论栗酮具有明显的调脂降脂及减轻脂肪肝的作用。更多还原

【Abstract】 Objective To investigate the effects of Litong on blood fat and cholesterol of rats suffering from adiposis hepatica induced by high fat diet.Methods The rat hyperlipidemia model was induced by intragastric administration of 4 % cholesterin and 30-40℃ pork fat.The model rats were divided into four groups: Litong groups(300 mg/kg,150 mg/kg,75 mg/kg) and model group.After 60 days administration,the serum total cholesterol,triglyceride,high and low density lipoprotein were detected.And the liparoid changes of livers were observed by eye and light microscopy after the rats were killed.Results Compared with the model group,the levels of total cholesterol,triglyceride and low density lipoprotein in 300 mg/kg and 150 mg/kg groups were decreased signif icantly.However,Litong had little effect on high density lipoprotein.Pathological results showed that Litong(300 mg/kg and 150 mg/kg) could obviously lighten the fatty degeneration of liver cells.Conclusion Litong can signifi cantly mediate and lower lipoid level and improve adiposis hepatica.更多还原