【摘要】 目的研究温度敏感型眼用即形凝胶产品的性能。方法测量试验品及不同泪液配合比样品的动力黏度、试验品的相变温度及热可逆性,评价其流变学特性以及与温度的关系。结果试验品的动力黏度在30℃以上时随温度升高迅速增加,37℃左右达到定值。随着人工泪液配合比增高,样品凝胶化温度逐步升高,温度升至30℃以上时试验品具有显著的成凝胶性能;成凝胶后温度降至25℃以下即可恢复原来的液体状态,缩小了相变范围,有利于产品使用和贮存。结论试验品的流变学特性、凝胶化温度、相变温度、热可逆性等特性均较好,具有温度敏感型即形凝胶剂型的典型特点,优于国外专利产品。更多还原

【Abstract】 Objective To investigate the characteristics of matrix in temperature-sensitive in situ forming eye gel.Methods The dynamic viscosity,sol-gel transition temperature,thermoreversibility of matrix and dynamic viscosity of matrix mixed with artificial tears were measured to research the rheological properties and relationship with temperature of the matrix.Results The dynamic viscosity of the matrix increased with the increasing of temperature above 33℃ and maintained constant at about 37℃;the gelation temperature rose with the increasing of artificial tears;sol-gel transition temperature was above 30℃ and gel-sol transition could happen when temperature lowered to 25℃,which further reduced the temperature range of phase change and helped the use and storage of eye gel.Conclusion The matrix in temperature-sensitive in situ forming eye gel possesses better characteristics in rheology,gelation temperature,sol-gel transition temperature and thermoreversibility compared with the foreign products.更多还原