【摘要】 目的研究首发吸烟精神分裂症患者的血清神经元特异性烯醇化酶(NSE)水平、认知功能及临床特征,探索吸烟与精神分裂症的关系。方法调查70例首发的男性精神分裂症患者的吸烟状况和临床资料,Fager-strom尼古丁依赖量表(FTND)评定吸烟患者尼古丁依赖程度,词汇流畅、视觉再生、数字广度、连线试验A和B、威斯康星卡片分类测验(WCST)5项神经心理测验评测认知功能,化学发光法检测血清NSE水平。结果①首发男性精神分裂症患者吸烟率为57.14%(40/70),75%(30/40)吸烟患者在起病前已吸烟,吸烟患者的发病年龄(24.87±6.45)岁低于非吸烟患者(30.86±7.39)岁(t=3.54,P<0.01);②吸烟与非吸烟患者各认知功能比较无差异;③吸烟患者的血清NSE水平(17.57±8.70)ng/ml高于非吸烟患者(12.68±4.21)ng/ml(t=2.83,P<0.01),并与FTND分呈正相关(r=0.39,P=0.011)。结论吸烟可能是精神分裂症的环境易感因素之一。更多还原

【Abstract】 Objective To study serum level of neuron-specific enolase,cognitive function and clinical characteristics in first-episode smoking schizophrenics,and to explore the relationship between smoking and schizophrenia.Methods The smoking status and clinical data in 70 male first-episode schizophrenic patients were investigated .Nic-otine dependence degree was rated by Fagerstrom Test for Nicotine Dependence(FTND) .Cognitive function were evalu-ated with 5 neuropsychological tests including semantic fluency,visual reproduction,digit span,Trail Making test A and B,Wisconsin Card Sorting Test( WCST) .The serum level of neuron-specific enolase was measured by automated chemiluminescent enzyme immunoassays.Results ①Smoking rate in male first-episode schizophrenics was 57.14% (40/70) and 75% (30/40) smoking patients started to smoke before the onset of their schizophrenic illness.Age at onset of illness in smoking patients (24.87±6.45 years) was significantly younger than that in non-smoking patients (30.86 ±7.39 years) (t=3.54,P <0.01) .② The performance of cognitive tests showed no significant differences between smoking patients and non-smoking patients.③The serum level of neuron-specific enolase in smoking patients (17.57±8.70ng/ml) was significantly higher than that in non-smoking patients (12.68±4.21ng/ml) (t=2.83,P<0.01) .The serum level of neuron-specific enolase in smoking patients was significantly positively correlated with score of FTND(r=0.39,P=0.011) .Conclusion Smoking may be one of environmental vulnerability factors for schizophrenia.更多还原