【摘要】 目的:探讨内分泌治疗在老年女性乳腺癌治疗中的价值。方法:回顾性分析704例70岁及以上老年女性乳腺癌患者的临床病理资料和系统的随访资料。结果:704例患者平均年龄77.8岁,其中70岁～79岁占88.9%。TNM分期Ⅰ期和Ⅱ期占76.1%;病理类型以浸润性导管癌和小管癌为主,占85.2%;腋下淋巴结转移率41.6%。手术以乳腺癌改良根治术和单纯切除术为主,占59.1%;术后局部并发症发生率为12.2%,主要为胸壁皮下或腋窝积液和切口部分皮瓣坏死。术后内分泌治疗占66.6%。术后2年、5年和10年生存率分别为92.8%、75.3%和69.5%。结论:内分泌治疗可以作为老年乳腺癌患者手术后的首选治疗方案,但尚需积累更多有关老年乳腺癌治疗的临床经验。更多还原

【Abstract】 Objective:To analyze the clinical characteristics of endocrine treatment and the prognosis of breast cancer in eldery women.Methods:The clinical follow-up data of 704 cases of women(70 years old or elder)with breast cancer(from January 1993 to December 2009 in our department)were retrospectively reviewed.Results:The mean age of the 704 patients was 77.8 years old and the rate of TNM stage Ⅰ and stage Ⅱ was 76.1 %.Modified radical mastectomy and simple ectomy were two important types of operation. The main pathological types were infiltrating ductal carcinoma and ductal carcinoma.The rate of lymph nodes metastasis was 46.1%.The incidence of postoperative complications was 12.2%.66.6% cases accepted tamoxifen and aromatase inhibitors(AIs) chemotherapy.The overall postoperative 2、3 and 5 years survival rates were 92.8%、75.3% and 65.9% respectively.Conclusion: Endocrine therapy is recommended as the main treatment for postoperative elderly women with breast cancer to achieve higher survival rates.更多还原