【摘要】 目的:探讨同期放化疗后行全肺切除的Ⅲ期非小细胞肺癌患者的临床效果。方法:回顾性分析1998年5月至2008年6月我院同期放化疗后行全肺切除的37例Ⅲ期非小细胞肺癌患者的临床资料。37例患者在术前接受了同期放化疗后再行全肺切除术,其中17例行右全肺切除(包括2例肺上沟瘤)。所有患者术前均接受同期放化疗,放疗平均总剂量60.1 Gy。结果:所有患者均接受了全肺切除以达到根治切除(R0)的目的,16例(43.2%)患者达到了病理完全缓解。无手术死亡,术后平均住院天数9.1天。术后90天死亡率为2.7%(n=1)。术后共有13例(35.1%)患者出现多处转移。包括脑转移7例,骨转移5例,肝转移2例,肾上腺转移2例,肺转移2例,颈部淋巴结转移1例和小肠转移1例。5年生存率为32%。结论:同期放化疗后行全肺切除术在临床上值得进一步研究。更多还原

【Abstract】 Objective:To study the clinical outcomes of patients undergoing pneumonectomy after preoperative concurrent chemoradiotherapy for stage Ⅲ non-small cell lung cancer.Methods:Clinical records of 37 patients with stage Ⅲ non-small cell lung cancer were reviewed retrospectively.They underwent pneumonectomy at our institution from May 1998 to June 2008 after preoperative concurrent chemoradiotherapy.There were 17 right pneumonectomies,of which 2 were for pancoast tumors.All patients received concurrent preoperative chemoradiotherapy.Mean total radiation dose was 60.1 Gy.Results;All patients went on to have complete(RO) resection by pneumonectomy.Pathologic complete response was found in 16 patients(43.2%).All patients were discharged alive from the hospital after pneumonectomy.Mean hospital length of stay was 9.1 days.Ninety-day mortality after surgery was 2.7%(n= 1).Metastases had been found in 13 patients(35.1 %),including brain metastases(n=7),bone metastases(n = 5),liver metastases (n=2),adrenal metastases(n=2),lung metastases(n=2),cervical lymphnode metastases(n=1)and small bowel metastases (n=1).Estimated overall survival rate was 32% at 5 years.Conclusion:Pneumonectomy can be performed feasibly after preoperative concurrent chemoradiotherapy.更多还原