【摘要】 目的探讨中药治疗对多脏器功能障碍(MODS)患者胃肠功能衰竭改善的影响。方法回顾分析121例危重病患者在治疗过程中,合并胃肠功能衰竭时加用中药组(治疗组,68例)与未加中药组(对照组,53例)。比较两组胃肠功能衰竭的缓解率、缓解时间及MODS的发生率、病死率、ICU住院时间等。结果治疗组胃肠功能衰竭的缓解率明显高于对照组(75.0%vs55.7%,P=0.027);治疗组比对照组胃肠功能衰竭的持续时间明显缩短[(2.52±2.10)dvs(10.85±3.85)d,P=0.00]、MODS的发生率明显减少(13.2%vs24.5%,P=0.027)、平均ICU住院时间明显缩短[(4.60±3.63)dvs(15.92±3.9)d,P=0.00];治疗组病死率与对照组比较差异无统计学意义(19.1%vs20.8%,P=0.741)。结论中药治疗结合常规治疗对危重病患者胃肠功能衰竭具有较好的治疗作用,可明显降低MODS的发生率、ICU住院时间,但对病死率无明显影响。更多还原

【Abstract】 Objective To investigate ameliorate of gastrointestinal failure in critical illness treated with traditional Chinese medicine.Methods Retrospective analysis of 121 cases of critical illness in the course of treatment,ameliorate of gastrointestinal failure,when combined with traditional Chinese medicine:treatment plus Chinese medicine group(treatment group 68 cases)and treatment without Chinese medicine group(control group of 53 cases).Compared two groups for the gastrointestinal function failure remission rate,remission duration and the incidence of multiple organ dysfunction system(MODS),mortality,and ICU hospitalization time.Results The remission rate of gastrointestinal failure 75.0% vs 55.7%,between the two groups was significant difference(P<0.01).For the treatment group,duration of gastrointestinal failure(2.52±2.10)d was significantly shorter,MODS incidence rate was lower(13.2%),the average ICU length of stay was shorter(10.85±3.85)d,than the control group(P<0.05).The treatment group mortality was 19.1% vs 20.8% in the control group;no significant difference between the two groups(P>0.05).Conclusion The traditional Chinese medicine combined with conventional therapy on gastrointestinal failure in critical illness have a better therapeutic effect can significantly reduce the incidence of MODS,and ICU length of stay.However no significant effect was shown on mortality.更多还原