【摘要】 目的探讨新辅助化疗治疗局部晚期乳腺癌的价值。方法对70例局部晚期乳腺癌患者采用多西紫杉醇75mg/m2静脉注射,d1;表阿霉素75mg/m2静脉推注,d1;环磷酰胺mg/m2静脉注射,d1。21d为1疗程,共3个疗程。结果新辅助化疗后70例中,总有效率为81.4%,有10例(14.3%)达到pCR。毒性反应主要是骨髓抑制、脱发及消化道反应。骨髓抑制以白细胞减少为主,经G-CSF处理后患者均能耐受,消化道反应经对症处理后患者均能耐受。结论多西紫杉醇与表阿霉素、环磷酰胺联合应用有协同作用,它对局部晚期乳腺癌有显著疗效,是值得推荐的新辅助化疗方案。更多还原

【Abstract】 Objective To study the valuation of neoadjuvant chemotherapy on locally advanced breast cancer.Methods 70 patients with locally advanced breast cancer were treated with Docetaxel 75mg/m2 by intravenous injection,d1;epirubicin 75mg/m2 by intravenous injection,d1;cyclophosphamide mg/m2 by intravenous injection,d1.21d as a course of treatment,Total in 3 courses.Results The total effective rate was 81.4% in 70 patients after neoadjuvant chemotherapy,10 cases(14.3%)achieved pCR.The main toxicity was myelosuppression,alopecia and gastrointestinal reactions.Leukopenia suppression was the maily myelosuppression effect.The patients treated with G-CSF could be tolerated well.The patients with gastrointestinal reactions could be tolerated well after symptomatic treatment.Conclusions It was Synergy effective for docetaxel combined with epirubicin and cyclophosphamide.And it was significant effective for locally advanced breast cancer.It is recommended neoadjuvant chemotherapy.更多还原